General Information About Carney Complex
Disease Details and Frequently Asked Questions
It is a multisystemic disease seen as the formation of benign connective tissue tumors (myxomas) in different parts of the body, pigmentation changes in the skin, and overactivity in hormone-producing glands due to a genetic mutation.
Dense dark brown spots (lentigo) on the face, lips, and around the eyes, Cushing's syndrome (weight gain) due to overactivity of the adrenal glands, thyroid nodules, and shortness of breath originating from the heart.
A benign tumor (myxoma) growing inside the heart chambers (usually the left atrium) can block blood flow, causing sudden heart failure, or pieces breaking off from the tumor can travel to the brain and cause a stroke.
Yes, in about 70% of cases, it is transmitted from generation to generation in an autosomal dominant manner as a result of a mutation in the gene called PRKAR1A.
When clinical findings arouse suspicion, Echocardiography is performed to detect tumors in the heart, endocrine blood tests are done for hormone levels, and genetic tests are conducted for a definitive diagnosis.
There is no single drug treatment for the complex. Treatment is directed at the emerging tumors. Especially myxomas detected in the heart pose a vital risk and must be removed immediately via open-heart surgery. Surgical intervention is also applied for hormone-producing masses.
Our health library contents are prepared for informational purposes only and with scientific data available at the time of recording. For all your questions, concerns, diagnosis, or treatment regarding your health, please consult your doctor or a healthcare institution.
