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Churg-Strauss Syndrome

Diagnosis, symptoms, and treatment methods.

General Information About Churg-Strauss Syndrome

Churg-Strauss syndrome (Eosinophilic Granulomatosis with Polyangiitis) is an autoimmune and allergic disease that causes inflammation of small and medium-sized blood vessels (vasculitis). It typically begins with asthma and allergic rhinitis, eventually causing damage to organs such as the lungs, nervous system, and heart. In our Rheumatology and Immunology departments, it is treated with cortisone and immunosuppressive drugs.

Disease Details and Frequently Asked Questions

You can access detailed information about the disease under the headings below.

It is a rare disease characterized by asthma and high levels of eosinophils (a type of white blood cell), where the body's immune system mistakenly attacks blood vessels, leading to inflammation.

Symptoms include severe asthma attacks lasting for years, nasal polyps, sinusitis, joint pain, skin rashes, and loss of sensation (neuropathy) in the hands and feet.

The exact cause is unknown. It is believed that allergens or infections overstimulate the immune system in individuals with a genetic predisposition, triggering this condition.

The respiratory tract is the most commonly affected area. In advanced stages, it can cause damage to the heart (myocarditis), kidneys, gastrointestinal system, and peripheral nerves.

It is suspected through extremely high levels of eosinophil cells and positivity for p-ANCA antibodies in blood tests. A definitive diagnosis is made by taking a biopsy from the affected tissue (skin or lungs).

High-dose cortisone (steroids) is used to stop the progression of the disease. In advanced cases with organ involvement, strong immunosuppressive drugs are added to the treatment regimen.

Our health library contents are prepared for informational purposes only and with scientific data available at the time of recording. For all your questions, concerns, diagnosis, or treatment regarding your health, please consult your doctor or a healthcare institution.

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