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Langerhans Cell Histiocytosis

Diagnosis, symptoms, and treatment methods.

General Information About Langerhans Cell Histiocytosis

Langerhans cell histiocytosis (LCH) is a rare disease where Langerhans cells of the immune system multiply uncontrollably, causing damage to tissues such as bone, skin, lungs, and the pituitary gland. It usually presents with bone lesions in childhood. It is managed by our Pediatric Oncology and Hematology councils using chemotherapy, corticosteroids, and local surgical methods.

Disease Details and Frequently Asked Questions

You can find detailed information about the disease under the headings below.
What is Langerhans Cell Histiocytosis?

It is the destruction of tissues by cells of the immune system forming tumor-like accumulations.

Is it Cancer?

It lies on a spectrum between cancer and an autoimmune disease. There is cancer-like cell proliferation.

What are the Symptoms?

Bone pain, persistent skin rashes, ear discharge, swollen lymph nodes, and excessive urination/diabetes insipidus.

Which Organs Does it Affect?

It can involve a single bone, or it can involve multiple organs such as bone marrow, liver, lungs, and the brain.

How is it Diagnosed?

Bone lesions are detected by X-ray/MRI; definitive diagnosis is made by biopsy taken from the lesion and immunohistochemical staining.

How is the Treatment?

If there is only bone involvement, it may be self-limiting or local curettage is performed. Chemotherapy and cortisone treatment are mandatory in systemic involvement.

Our health library contents are prepared for informational purposes only and with scientific data available at the time of recording. For all your questions, concerns, diagnosis, or treatment regarding your health, please consult your doctor or a healthcare institution.


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