General Information About Progeria
Disease Details and Frequently Asked Questions
It is an extremely rare genetic disorder beginning in childhood, where the body's biological aging process progresses much faster than normal (about 8 times faster), giving patients the appearance of an elderly person.
It is caused by a random mutation (alteration) in a gene called LMNA (Lamin A), leading to the production of a toxic protein called Progerin, which disrupts the nuclear structure of cells.
The baby appears normal at birth, but growth halts around 1-2 years of age. Hair, eyebrows, and eyelashes fall out completely; the skin thins and wrinkles; the nose assumes a beak-like shape; the eyes become prominent, and the head remains disproportionately large compared to the body.
Internal organs (especially blood vessels) age just as much as external physical appearance. A child with Progeria at the age of 12-13 has the atherosclerosis (hardening of the arteries) of an 80-year-old and usually dies from a heart attack or stroke.
No. Brain development and intelligence of children with Progeria are completely normal; the disease has no negative impact on mental functions.
There is currently no genetic cure for the disease. Treatment is based on supportive methods that protect the cardiovascular system, such as cholesterol-lowering drugs and aspirin. New-generation drugs aimed at preventing the accumulation of progerin in cells can extend life expectancy to some extent.
Our health library contents are prepared for informational purposes only and with scientific data available at the time of recording. For all your questions, concerns, diagnosis, or treatment regarding your health, please consult your doctor or a healthcare institution.
