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Bone Marrow Transplant (Stem Cell Transplant)

About the Treatment Method

Bone Marrow (Stem Cell) Transplant; in leukemia (blood cancer), lymphoma, multiple myeloma, or severe aplastic anemia diseases, is the process of giving fresh and healthy blood-forming stem cells taken from the patient themselves (Autologous) or from a healthy donor whose tissue perfectly matches (Allogeneic), to replace the patient's marrow, which either cannot produce its own blood or is completely emptied and reset by giving very high-dose chemotherapy.

Transplant Processes and Immunity

Stages of collecting and transplanting stem cells.
Is the transplant procedure done with a surgical operation (by opening the bone)?

No, this is a very common misconception in society. The collected stem cells are given to the patient simply intravenously (through a catheter), just like giving a normal blood transfusion or serum. Smart stem cells circulate through the bloodstream, autonomously go directly into the marrow cavities inside the bones, and settle there (engraftment process). There is no surgery with a scalpel involved.

What is the difference between Autologous and Allogeneic transplant?

In an autologous transplant; before the patient receives heavy chemotherapy, their own clean stem cells are collected by a machine and frozen, and when the treatment is finished, they are given back to the patient so that the bone marrow does not collapse (they save themselves). In an allogeneic transplant, the patient's marrow is cancerous; stem cells taken from a relative whose tissue group (HLA) matches or from a healthy foreign donor found from an international bone marrow bank (TÜRKÖK) are used.

Is the post-transplant process dangerous?

The first 2 to 4 weeks after the transplant are critical and challenging. Because the old marrow has been reset and the new stem cells have not yet started producing blood cells, the patient's immune system is at zero. During this period, because the patient could lose their life even from a simple flu, they live in sterile (HEPA filtered) rooms completely isolated from the outside world.

Is it risky for a healthy donor to give bone marrow?

Being a donor today is extremely easy and safe. 90% of stem cells are collected by a method called "Apheresis" (blood is drawn from one arm, passed through a machine, and given back from the other arm) while sitting for about 3-4 hours. In most cases, there is no need for surgery, anesthesia, or drilling into the bone.

The information on this page is for general health advice. Please consult specialized physicians for personalized treatment or advice.


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