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PIPAC (Pressurized Intraperitoneal Aerosol Chemotherapy)

About the Treatment Method

PIPAC is an innovative palliative treatment applied in advanced-stage cancer cases where stomach, bowel, or ovarian cancers have spread to the abdominal membrane (peritoneum), classic intravenous chemotherapy does not work, and the patient's general condition cannot handle major surgeries (like HIPEC). The chemotherapy drug is sprayed into the abdomen as a "pressurized gas (spray/aerosol)" via closed surgery (laparoscopy) rather than as a liquid.

Spray Chemotherapy Era in Cancer

The working principle of the PIPAC method and its differences from HIPEC.

For HIPEC (Heated Chemotherapy), the abdomen must first be opened completely from end to end, and the tumors inside must be cleaned with surgery lasting for hours (it is a very heavy surgery). PIPAC, on the other hand, is the procedure of spraying the medicine directly into the abdomen as a spray for 30 minutes by entering with a camera through only 2 small holes (laparoscopically) without performing surgery on the patient. The patient can go home the next day.

The gas (aerosol) form penetrates microscopically into the smallest folds of the abdomen, into every nook and cranny where liquid chemotherapy cannot reach. In addition, thanks to the applied "pressure", the chemotherapy drug is ensured to penetrate (inside) the tumor tissue to a depth of millimeters.

PIPAC is generally a palliative procedure, not curative (providing full healing). Its purpose is to shrink the tumors surrounding the abdomen, stop the constant fluid accumulation (ascites) in the patient's abdomen, relieve pain, and increase the patient's survival time/quality of life. It is mostly applied in 3 sessions with intervals of 6 weeks.

The information on this page is for general health advice. Please consult specialized physicians for personalized treatment or advice.

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