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Gamma-Glutamyl Transferase (GGT) Test

General Information About the Test

Gamma-Glutamyl Transferase (GGT) is an enzyme primarily found in liver, bile duct, and pancreas cells. An elevated GGT level in the blood is a very sensitive indicator that there is an obstruction (e.g., gallstones) or inflammation in the biliary tract, or that the liver has been damaged due to exposure to toxic substances (especially alcohol and certain heavy medications).

Test Process and Preparation

GGT enzyme test process and interpretation of results.
Does alcohol use affect the GGT level?

Yes. GGT is the liver enzyme most sensitive to alcohol consumption. In chronic alcohol users, the GGT level can be very high even if the liver has not yet sustained permanent damage (cirrhosis). When alcohol is stopped, the values return to normal within weeks.

What is the relationship between the GGT and ALP (Alkaline Phosphatase) tests?

The ALP enzyme also increases in bone diseases. In a patient with an elevated ALP level, the GGT test is checked to determine whether this elevation originates from the bone or the liver. If the GGT is also high, the problem is definitively of liver/bile origin.

Is fasting required for the test?

Since eating can temporarily affect the GGT level, albeit slightly, and because this test is usually requested along with other liver panels, performing it after an 8-10 hour fast yields the most accurate result.

The information on this page is for informational purposes only. The results of medical tests must be evaluated by specialist physicians.


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