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Lipase (LPS) Test

General Information About the Test

Lipase (LPS) is a special enzyme produced by the pancreas to ensure that the fats we consume are digested and absorbed in the intestines. Measuring the lipase level in the blood is a more sensitive and specific (unique to the pancreas) test than the amylase test for diagnosing "Acute Pancreatitis" (inflammation of the pancreas), especially in patients presenting to the emergency room with severe abdominal pain that radiates to the stomach and back.

Test Process and Preparation

Lipase enzyme measurement and diagnosis of pancreatitis.
What is the difference from the amylase test?

Both are requested in cases of pancreatic diseases. However, while amylase can also rise due to salivary gland or intestinal problems, the margin of error in indicating pancreatic diseases is much lower for the lipase enzyme (it is more specific) because it is almost entirely secreted by the pancreas.

What causes elevated lipase?

Diseases such as gallstones blocking the pancreatic duct, excessive alcohol consumption, pancreatic cancer, or cystic fibrosis disrupt the structure of the pancreas, causing the lipase enzyme to mix into the blood at high levels.

Is fasting required for the test?

Because it is an enzyme that plays an active role in the digestion of fats, your doctor will generally ask you to fast for an 8 to 12 hour period before giving blood in order to obtain an accurate result.

The information on this page is for informational purposes only. The results of medical tests must be evaluated by specialist physicians.


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