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Rheumatoid Factor

General Information About the Test

Rheumatoid Factor (RF) is an autoantibody that appears in the blood when the immune system mistakenly attacks its own healthy body tissues (especially the joints). It is requested by rheumatologists to help diagnose various autoimmune diseases, primarily Rheumatoid Arthritis (inflammatory rheumatism) and Sjogren's Syndrome, and to predict the severity of the disease.

Test Process and Preparation

Rheumatism blood test drawing process and interpretation of results.
Is elevated RF definitively rheumatism?

No. Although an elevated Rheumatoid Factor is seen in a large portion of rheumatoid arthritis patients, it can also be positive due to chronic infections (hepatitis, tuberculosis), advancing age, and sometimes even in completely healthy individuals. Therefore, it must be supported by the Anti-CCP test and clinical examination for a diagnosis.

If the test result is negative, does it mean there is no rheumatism?

In about 20% of patients, although Rheumatoid Arthritis is clinically present, the RF test in the blood may be negative (normal). This condition is called "Seronegative Rheumatoid Arthritis."

Should I give blood on an empty stomach?

Fasting is not mandatory for the RF test. It can be performed on a blood sample taken at any time of the day.

The information on this page is for informational purposes only. The results of medical tests must be evaluated by specialist physicians.


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